However, their effects on human drug metabolizing enzyme (DME) activities have not been elucidated. Group II: as paracetamol group received paracetamol intraperitoneally (i.p.) Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Its large effect was not limited to stool symptoms, and Descurainia sophia had a large effect on rectal symptoms and a moderate effect on abdominal symptoms (Table 2). Objectives: To clinically compare D. sophia with PEG 4000 (without electrolyte) in pediatric constipation and to assess its efficacy and side effects. Hashem Dabaghian, F, Taghavi Shirazi, M, Amini Behbahani, F, Shojaee, A. Zarshenas, MM, Petramfar, P, Firoozabadi, A, Moein, MR, Mohagheghzadeh, A. Pasalar, M, Bagheri Lankarani, K, Mehrabani, D, Tolidei, H, Naseri, M. Frank, L, Kleinman, L, Farup, C, Taylor, L, Miner, P. Cohen, J . Vergleichende Chorologie der zentraleuropäischen Flora. U.S. Department of Agriculture, Forest Service, Rocky Mountain Research Station, Fire Sciences Laboratory (Producer). Introduction: In this study, we aimed to evaluate the protective effects of Descurainia sophia seed extract on paracetamol-induced oxidative stress and acute liver injury in mice.Methods: Sixty male Swiss albino mice were divided into 6 groups, group I: as control group received NaCl 9%. All authors edited and approved the final version of the article. "Roadsides, waste places, disturbed sites, railroad embankments, hillsides, mountain slopes, canyon bottoms, stream banks, fields, lawns, pastures, deserts, sagebrush and pinyon-juniper communities; 0 … 22. Fifty five (98.2%) children in D. sophia and 50 (94.3%) in PEG group had a history of constipation for more than six months. 3 vols. The proportion of patients that had an average increase ≥1 CSBMs/week (71.4%) was also a noticeable result, compared with previous studies30–33 (<50%). The email address and/or password entered does not match our records, please check and try again. The sample passed all the necessary laboratory items according to the Iran Herbal Pharmacopeia and the World Health Organization. 6, No. cm. All authors edited and approved the final version of the article. Descurainia sophia var. For its subscales scores, the proportions of patients that had ≥1 point reduction were 12% for abdominal, 14% for rectal, and 23% for stool symptoms. Journal of Evidence-Based Complementary & Alternative Medicine, Epidemiology of constipation in Europe and Oceania: a systematic review, An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking, Epidemiology of constipation in North America: a systematic review, Prevalence of constipation: agreement among several criteria and evaluation of the diagnostic accuracy of qualifying symptoms and self-reported definition in a population-based survey in Spain, Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC), The assessment prevalence of functional constipation and associated factors in adults: a community-based study from Kerman, Southeast, Iran (2011-2012), Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders, Functional Constipation, Complementary and alternative treatments for motility and sensory disorders, Viewpoints of traditional Iranian medicine (TIM) about etiology of pediatric constipation, Abbasian A. viewpoints of Iranian traditional medicine (ITM) about etiology of constipation, Interventions of Iranian traditional medicine for constipation during pregnancy, Phytochemical and pharmacological aspects of, Types of headache and those remedies in traditional Persian medicine, Experimental research on pharmacology and acute toxicology of, Flixweed vs. polyethylene glycol in the treatment of childhood functional constipation: a randomized clinical trial, The functional gastrointestinal disorders and the Rome III process, Psychometric validation of a constipation symptom assessment questionnaire, Diagnostic value of bioelectrical impedance analysis versus body mass index for detection of obesity among students, Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies, A novel sulphur glycoside from the seeds of, Polyethylene glycol versus paraffin for the treatment of childhood functional constipation, Polyethylene glycol 4000 treatment for children with constipation: a randomized comparative multicenter study, Lactulose versus polyethylene glycol for chronic constipation, A placebo-controlled trial of prucalopride for severe chronic constipation, Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation–a 12-week, randomized, double-blind, placebo-controlled study, Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives, A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation, Stool form scale as a useful guide to intestinal transit time, Bristol scale stool form. The primary efficacy endpoint was the proportion of patients achieving 3 or more CSBMs/week. The trial was conducted in compliance with Declaration of Helsinki Good Clinical Practice guidelines at the Department of Gastroenterology in Shariati Hospital and Shariatpanahi Iranian Traditional Medicine Clinic in Tehran. An ethanol extract complex of Descurainia sophia seeds and Peucedanum praeruptorum roots, called BP10A, has antitumor potential against colorectal cancer. Statistical Power Analysis for the Behavioral Sciences. Descurainia sophia is safe and effective in the treatment of chronic functional constipation. Rezervace, chráněná území a jiné významné botanické lokality. The high proportion of patients that had an improvement of ≥1 point reductions on average, in overall, abdominal, rectal, and stool subscales was the most important result obtained from this research. It has also healing effect on wounds and injuries [23] and bedsores [22], removed uterine discharges [23], facilitated childbirth [32], and has demonstrated inhibitory effects on … The components of BP3B are Descurainia sophia seed, Peucedanum radix (Peucedanum praeruptorum Dunn. ) With regard to high safety of Descurainia sophia seed use as a medication up to 2500 mg/kg of body weight,12,25 for this study we asked patients to increase the dose to provide their satisfaction up to 60 mL by the measure (≈50 g). FundingThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors thank the financial support (Grant No. The seeds of Descurainia sophia are traditionally used to treat coughs, asthma and edema, but their effects on asthma have not been investigated by multi-omics analysis. Author ContributionsAll authors discussed the concept of the study. Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. This product could help you, Accessing resources off campus can be a challenge. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions, If you have access to journal content via a university, library or employer, sign in here, Research off-campus without worrying about access issues. Available: https://www.fs.fed.us/database/feis/plants/forb/dessop/all.html [2020, June 2]. Before the start of treatment, 62.9% of the patients did not use any laxatives and 25.7% of them used ≥3 laxatives/week (data not provided). Descurainia sophia L. known commonly as flixweed acts as first-line medical treatment for constipation in Iranian traditional medicine. It is also used in mixtures of Chinese herbs to prevent lung Descurainia sophia (L.) Webb et Berth (D. sophia) is a safe recommended medicine in Iranian folk and Traditional Persian Medicine for the treatment of constipation. Members of _ can log in with their society credentials below, Journal of Evidence-Based Integrative Medicine, This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (. The primary efficacy endpoint was the proportion of patients reaching 3 or more CSBMs/week. The means of frequency of CSBMs/week before and after treatment are shown in Table 3 (0.51 and 3.49, respectively, P < .001 by Wilcoxon signed-rank test). Conventional treatment such as lifestyle changes such as increasing regular physical activity and fiber and fluid intake in the diet or pharmacological intervention such as using laxatives do not satisfy all patients with their treatment. The enrolled patients included patients aged 18 to 75 years with chronic functional constipation defined based on Rome III criteria for functional constipation.19 Patients should have had 2 or more of the following symptoms during 25% or more of their bowel movements for at least the past 6 months: less than 3 spontaneous complete bowel movements per week (CSBMs/week), hard/lumpy stools, straining during defecation, and sensation of incomplete evacuation. We calculated body mass index using the followed equitation: body mass index = weight (kg)/(height (m2))2 and categorized them according to the World Health Organization body mass index principal cutoff points.22 Although current cutoff points of overweightness and obesity may be not suitable in the Persian population,23 as it is not in many Asian populations,24 with regard to minimal data about the suitable cutoff points for Iranian population, we decided to use aforementioned points as a general standard. The other major limitation of this study was its short period of treatment. This condition affects different population groups ranging from a low of 0.7% to a high of 81%.1 In the general population, the mean value of chronic constipation prevalence including patient-reported or based on various existing definition criteria is estimated at 12% to 30% of the population,1–4 and for its subtype functional constipation, it is 4.6% to 17%.2,5 Although functional constipation prevalence has not been globally investigated in Iran, recently in Kerman, the biggest city in the Southeast of Iran, it has been estimated at over 9.4%.6 Functional constipation is a heterogeneous condition that, beyond generally decreased frequency of defecation, includes a diversity of symptoms such as bloating, straining, abdominal pain, a feeling of incomplete evacuation, and hard or lumpy stools.7 Despite constipation not being a life-threatening condition, because of its negative effect on patients’ quality of life that subsequently leads to great economic consequences,1 its treatment is considered very important by health providers. It seems that D. sophia L. can modify the digestion process and patients can excrete large amounts of the substance that causes warts. It seems that D. sophia L. can modify the digestion process and patients can excrete large amounts of the substance that causes warts.Therefore, it is better to use it more than 40 days. documented that decoction of Descurainia sophia (L.) has antipyretic, anti-inflammatory and analgesic activities (Mohamed et al., 2009). effects of Descurainia sophia on small cell carcinoma of the lung [28,29], colon cancer [30], and glioma [31] have been proved. The Descurainia sophia seeds were bought from a local famous market in Tehran, Iran, and were authenticated by Dr Homa Hajimehdipoor, analyzed for physicochemistry quality control and microbial restriction tests. We undertook this study to assess the epigenetic effects of ethanol extract of D. sophia seeds (DSE) in an ovalbumin (OVA)-induced mouse model of asthma. The mechanism of Descurainia sophia has not yet been exactly known. Descurainia sophia seed, also known as flixweed, is a member of Brassicaceae family. The trial was registered at the Iranian Registry of Clinical Trials (www.irct.ir/; unique registration number: IRCT2016030515408N2). Tack, J, Van Outryve, M, Beyens, G, Kerstens, R, Vandeplassche, L. View or download all content the institution has subscribed to. The trial was conducted in compliance with Declaration of Helsinki Good Clinical Practice guidelines at the Department of Gastroenterology in Shariati Hospital and Shariatpanahi Iranian Traditional Medicine Clinic in Tehran. One patient reported an increase in severity of her constipation and withdrew from the study. Hultén E, Fries M. 1986. In conclusion, in patients with a mean age of 47 years, a history of moderate to severe constipation, 50% of whom were obese and over weighted, Descurainia sophia significantly improved frequency of CSBMs/week and symptoms associated with chronic constipation. Then the seeds were filled into plastic boxes and with a measure were offered to the cooperative patients. For its subscales scores, the proportions of patients that had ≥1 point reduction were 12% for abdominal, 14% for rectal, and 23% for stool symptoms. Background: Descurainia sophia seeds have a variety of pharmacological functions and been widely used in traditional folk medicine. You can be signed in via any or all of the methods shown below at the same time. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. The primary efficacy endpoint was the proportion of patients reaching 3 or more CSBMs/week. AUTHORSHIP AND CITATION: Howard, Janet L. 2003. In conclusion, in patients with a mean age of 47 years, a history of moderate to severe constipation, 50% of whom were obese and over weighted, Descurainia sophia significantly improved frequency of CSBMs/week and symptoms associated with chronic constipation. Ethanolic extract of Descurainia sophia seeds sensitizes A549 human lung cancer cells to TRAIL cytotoxicity by upregulating death receptors. This plant is native to Asia, Africa, and Europe and is generally used as food additive and a medicinal herb in Iranian, Chinese, and Indian traditional medicines. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? If available other names are mentioned here Flaxweed tansymustard; flixweed tansymustard; herb-Sophia; herb-sophia; pinnate tansymustard. Zajímavosti ze světa rostlin. 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